Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Stevens-Johnson syndromeUpdated: 2020-04-14OverviewStevens-Johnson syndrome is a serious disorder of the skin and mucous membranes. A medical emergency, it's often a reaction to medication or an infection.SymptomsFlu-like symptoms appear first. A painful rash that spreads and blisters follows.TreatmentsEmergency treatment aims to eliminate the underlying cause and control symptoms and complications. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use