Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Squamous cell carcinoma of the skinUpdated: 2021-03-18OverviewSquamous cell carcinoma of the skin is a common, treatable form of skin cancer that develops in the thin, flat squamous cells that make up the outer skin layer. Too much exposure to UV radiation from the sun or tanning lamps is a cause.SymptomsIt can appear as a nodule, sore, or rough patch on the skin.TreatmentsTreatments include topical medication and minor surgery. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use