Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs SclerodermaUpdated: 2017-06-13OverviewScleroderma is a group of rare diseases that involve the chronic hardening and tightening of the skin and connective tissues. Scleroderma more often affects women and commonly occurs between the ages of 30 and 50.SymptomsSymptoms vary, depending on which body areas are affected.TreatmentsTreatment includes medication, physical therapy, and surgery. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use