Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Premenstrual dysphoric disorderUpdated: 2017-06-13OverviewThe cause of PMDD isn't clear. It's possible that hormonal changes worsen underlying mood disorders such as anxiety and depression. SymptomsPMDD causes extreme mood shifts that can disrupt work and damage relationships. Symptoms include extreme sadness, hopelessness, irritability, or anger, plus common PMS symptoms. TreatmentsPrescription drugs and lifestyle changes may help. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use