Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Neuroleptic malignant syndromeUpdated: 2017-06-13OverviewNeuroleptic malignant syndrome is a serious nervous system reaction to certain drugs. These include tranquilizing and antipsychotic drugs.SymptomsSymptoms include high fever, unstable blood pressure, and rigid muscles.TreatmentsHospital treatment is frequently necessary. Use of the drug causing the reaction is stopped and other symptoms are treated. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use