Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Harlequin-type ichthyosisUpdated: 2017-06-13OverviewHarlequin ichthyosis is a condition in which a newborn has hard, thick skin in diamond patterns.The condition prevents skin from properly protecting the body.SymptomsAffected newborns are prone to dehydration and infections.TreatmentsHospitalization is required. Medications and IV fluids can help. Tube feeding may be needed. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use