Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Bubonic plagueUpdated: 2017-06-13OverviewBubonic plague is a rare but serious bacterial infection that's transmitted by fleas.SymptomsSymptoms include swollen lymph nodes, as large as chicken eggs, in the groin, armpit, or neck. They may be tender and warm. Others include fever, chills, headache, fatigue, and muscle aches.TreatmentsIt requires urgent hospital treatment with strong antibiotics. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use