Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs SSRI discontinuation syndromeUpdated: 2017-06-13OverviewSSRI discontinuation syndrome refers to symptoms that may occur when a person stops taking SSRI antidepressants.SymptomsSymptoms can be flu-like and include nausea, sleeplessness, anxiety, and irritability.TreatmentsIt may be avoided by a slow reduction of the amount of antidepressant or by a switch to another SSRI drug. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use