Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs Sickle cell anemiaUpdated: 2020-01-30OverviewWith sickle cell disease, an inherited group of disorders, red blood cells contort into a sickle shape. They die early, leaving a shortage of healthy red blood cells (sickle cell anemia), and can block blood flow.SymptomsInfections, pain, and fatigue are symptoms.TreatmentsTreatments include medications, blood transfusions, and bone marrow transplant. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use