Menu Healthy Lifestyle Diseases & Conditions First Aid Symptoms Tests & Procedures Videos Definitions FAQs SeromaUpdated: 2017-06-13OverviewSeroma is a tumorlike accumulation (mass) of fluid under the skin. It may occur as a complication of surgery, beneath an incision site.SymptomsSymptoms may appear a few days later. They include swelling and pain. Fluid may leak from the incision.TreatmentsTreatments may include draining the fluid and antibiotics. © 1998-2022 Mayo Foundation for Medical Education and Research(MFMER). All rights reserved. Terms of Use