DefinitionThis is a test that measures the amount of amylase in urine. Amylase is an enzyme that helps digest carbohydrates. It is produced mainly in the pancreas and the glands that make saliva.Amylase may also be measured with a blood test. See: Amylase - blood
How the test is performedA urine sample is needed. The test may be performed using a single urine sample or a 24-hour urine collection. For information on how to collect a sample, see:Clean-catch urine test24-hour urine collection
How to prepare for the testYour health care provider may tell you to stop taking certain drugs that can affect test results. Drugs that can increase amylase levels include:AsparaginaseAspirinBirth control pillsCholinergic drugsCodeineCorticosteroidsIndomethacinLoop and thiazide diureticsMethyldopaMorphinePentazocine
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performedThis test is done to diagnose pancreatitis and other diseases that affect the pancreas. Your doctor may also order this test to see how treatment for such conditions is working.
Normal ValuesThe normal range is 2.6 to 21.2 international units per hour (IU/h).Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
What abnormal results meanAn increased amount of amylase in the urine is called amylasuria. Increased amylase levels may be a sign of:Acute pancreatitisAlcohol consumptionCancer of the pancreas, ovaries, or lungsCholecystitisEctopic or ruptured tubal pregnancyGallbladder diseaseInfection of the salivary glands (called sialoadenitis, may be caused bymumps or a blockage)Intestinal obstructionPancreatic duct obstructionPelvic inflammatory diseasePerforated ulcerDecreased amylase levels may be due to:Damage to the pancreasKidney diseasePancreatic cancerToxemia of pregnancy
What the risks areThere are no risks.
ReferencesOwyang C. Pancreatitis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 147.Tenner S, Steinberg WM. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 58.