DefinitionAgranulocytosis means a failure of the bone marrow to make enough white blood cells (neutrophils). Bone marrow is the soft tissue inside bones that helps form blood cells.
Alternative NamesGranulocytopenia; Granulopenia
Causes, incidence, and risk factorsAgranulocytosis may be caused by:Autoimmune disordersBone marrow diseases such as myelodysplasia or large granular lymphocyte leukemiaChemotherapy and bone marrow transplantationMedications such as rituximab, penicillin, captopril, ranitidine, cimetidine, methimazole, and propylthiouracilPreparation for bone marrow transplantAgranulocytosis results in a person not having enough of a specific type of white blood cells, called neutrophils or granulocytes. A low neutrophil count (neutropenia) may also occur when white blood cells are destroyed faster than they can be produced.
SymptomsPersons with this condition are more likely to have fevers and infections.
Signs and testsSee: Blood differential test
ReferencesAndersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-665.Berliner N. Leukopenia and leukocytosis. In Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 170.